Loss of Dlg-1 in the Mouse Lens Impairs Fibroblast Growth Factor Receptor Signaling
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چکیده
منابع مشابه
Loss of Dlg-1 in the Mouse Lens Impairs Fibroblast Growth Factor Receptor Signaling
Coordination of cell proliferation, differentiation and survival is essential for normal development and maintenance of tissues in the adult organism. Growth factor receptor tyrosine kinase signaling pathways and planar cell polarity pathways are two regulators of many developmental processes. We have previously shown through analysis of mice conditionally null in the lens for the planar cell p...
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PURPOSE We previously showed that Discs large-1 (Dlg-1) regulates lens fiber cell structure and the fibroblast growth factor receptor (Fgfr) signaling pathway, a pathway required for fiber cell differentiation. Herein, we investigated the mechanism through which Dlg-1 regulates Fgfr signaling. METHODS Immunofluorescence was used to measure levels of Fgfr1, Fgfr2, and activated Fgfr signaling ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0097470